Fenbendazole is an animal anthelmintic that has been shown to kill cancer cells in lab experiments. It is also effective against parasitic infections.
In this study, mice were injected with EMT6 tumors and given three daily i.p. injections of fenbendazole alone or with irradiation. The growth of unirradiated tumors was not altered by fenbendazole, but irradiation significantly decreased the number of lung metastases in the mice.
Mechanism of action
The results show that fenbendazole and its commercial formulation, which is used as an antihelmintic drug, exhibit cytotoxic effects against different types of human cancer cells. Cell viability data showed a decrease in the number of viable cells at higher doses and long incubations. The fenbendazole-induced viability reductions were enhanced in hypoxia, indicating that fenbendazole is an effective anticancer drug even in the presence of cellular hypoxia.
Mebendazole acts by disrupting the function of tubulin, which is both the microskeleton of the inner cell and a highway for transport. Mebendazole prevents tubulin polymerization, cutting off the parasite’s supply of nutrition and starving it to death. In pancreatic cancer, fenbendazole may act in the same way by disrupting the structure of tumor cells and limiting their growth. In addition, the drug can help block cell-cycle progression by inhibiting the phosphorylation of CDK1. The research was funded by the Virginia and D.K Ludwig Fund for Cancer Research.
Originally used to fight roundworm, hookworm, and other parasitic infections, mebendazole works by binding to tubulin and disrupting its microtubule equilibrium. It cuts off the parasite’s supply of nutrition and starves it to death. This mechanism may also work in cancer cells by blocking the growth of microtubules.
However, there is no evidence that fenbendazole can cure cancer in humans. Although it can have positive effects on cancer in cell culture, it has never been tested as a treatment for human patients.
A video circulating on TikTok and Facebook claims that a dog deworming drug can cure cancer in humans. The drug, fenbendazole, is approved by the Canadian government as an antiparasitic medication for dogs. It has not been tested for use in human cancer, and experts warn that it could have dangerous side effects. The video’s claim is false and has no scientific basis. In fact, it’s been shown to be no more effective than a placebo.
The fenbendazole for humans cancer drug was found to be cytotoxic to human cancer cells in the laboratory, but it is not known whether this cytotoxicity extends to people. It is used as a parasitic dewormer in dogs and may kill cancer cells by blocking the formation of tubulin, which acts as the cell’s micro-skeleton and highway for transporting chromosomes during mitosis.
Despite some anecdotal reports from people who have claimed that fenbendazole has helped them overcome cancer, researchers are skeptical. According to the nonprofit Cancer Research UK, there is insufficient evidence that fenbendazole cures cancer. The evidence is based on experiments using human cancer cells in petri dishes and mice. The drug is also not approved by the U.S. Food and Drug Administration for use as a cancer treatment. In addition, the remissions seen in these anecdotal cases are often the result of other conventional cancer treatments, such as immunotherapy or chemotherapy. A video circulating on TikTok and Facebook shows a veterinarian in Canada claiming that dog deworming medicine, fenbendazole, can treat advanced lung cancer.
Fenbendazole is an anthelmintic drug that has a broad antiparasitic spectrum. It also has cytotoxic properties against some cancer cells. It inhibits the activity of microtubules and blocks cell division. This is why it is effective against certain types of cancer. The drug is not safe for humans, however. A woman who took fenbendazole for a month experienced severe liver dysfunction.
This study aims to evaluate the cytotoxic effect of commercially available fenbendazole on human cancer cells. It also explores formulation issues that hinder distribution in the human body. Qualitative and quantitative analysis of the formulations of two commercial brands (brand P and brand S) were conducted by HPLC, LC-MS, and NMR.
The results of this study indicate that fenbendazole has a good solubility in dimethyl sulfoxide. In addition, it has a good encapsulation efficiency in mPEG-b-PCL micelles. The fenbendazole/rapamycin-loaded M-FR has an average particle size of 37.2 +- 1.10 nm, zeta potential of -0.07 +- 0.09 mV, and a polydispersity index of 0.20 +- 0.02. The fenbendazole/rapamycin-loaded micelle also enhanced the cytotoxicity of rapamycin against human cancer cells.